Best GLP-1 Weight Loss Programs Online, Compared
The best online weight loss program is the one whose price, prescriber support and plan terms fit your situation; the medication is only one part of the choice. Top Weight Loss compares GLP-1 providers on monthly cost, clinical support, treatment plans, eligibility rules and long-term value, because these differ widely from one provider to the next. For a quick starting point, our provider matching quiz recommends a program based on your answers.
Each program in our ranking is assessed on medication access, affordability, prescriber support, customer experience and overall value. Our full provider reviews cover each program in detail, and head-to-heads such as altRx vs embody show two programs side by side. Want the evidence without scores? The GLP-1 provider comparison lines up eight providers on verified prices, Trustpilot patterns, Reddit experiences and cancellation terms, and the GLP-1 price index keeps every verified price together with a public record of each change.
The aim is simple: help you find the provider that matches your health goals, your budget and the way you want to be treated.
How Much Do Online GLP-1 Weight Loss Programs Cost in 2026?
Monthly prices in our ranking start at $49 for semaglutide and $89 for tirzepatide, both at welludr on its 12-month plan. Each figure below is the price published on the provider's own site, not an estimate. Most plans bundle the prescription, clinician consultations, ongoing support and home delivery into a single monthly fee.
| Provider | Semaglutide | Tirzepatide | Pricing model |
|---|
| welludr | $49/mo | $89/mo | Best rate requires a 12-month plan |
| embody | $69/mo | $119/mo | Flat monthly price, no commitment |
| altRx | $89/mo | $149/mo | Same price at every dose, buy now pay later |
| Medvi | $99/mo promo (reg. $199) | $166/mo promo (reg. $299) | All-inclusive, with a dietitian |
| HealthRx | $99/mo | from $179/mo | Prepaid for 12 months |
| DirectMeds | $147/mo | $147/mo | Flat price, needle-free option |
| Sprout | $149/mo | $199/mo | Brand-name Wegovy also available |
| TrimRx | $149/mo at every dose | $259/mo | No contract |
| SHED | $199/mo | $299/mo | Results guarantee with money back |
Prices as published and verified on October 16, 2026. Check current pricing on each provider's site before you sign up. For yearly totals and a closer look at the budget options, see the cheapest verified GLP-1 comparison.
How Do You Choose a GLP-1 Telehealth Provider?
Start with the one thing every legitimate online weight loss clinic has in common: a licensed clinician reviews your health intake before anything is prescribed. After that, five checks set the strongest telehealth weight loss providers apart:
- An all-inclusive price, published up front:a real monthly figure on the site, not a "from" price that climbs at checkout
- Genuine prescriber review: a licensed clinician, and a provider prepared to turn down treatment when it is not appropriate
- Clear pharmacy sourcing: US-licensed 503A compounding pharmacies that are named or can be verified
- Support you can reach: help with dose changes and side effects, and a real person to contact
- Shipping suited to the medication: tracked, insured and kept cold where required
Our full ranking methodology shows how each check is scored. Short on time? The 60-second matching quiz factors in your budget and priorities, and our step-by-step guide to choosing a telehealth weight loss provider walks through the whole decision.
What Should You Know Before Starting a GLP-1?
GLP-1 medications need a prescription from a licensed clinician, and they are not right for everyone. Side effects can occur, most often during the first few weeks while the body adjusts.
These medications generally work best alongside everyday habits such as balanced eating and regular physical activity.
For both safety and lasting results, choose a provider that screens you properly before prescribing and follows up with you throughout treatment.
What Should You Weigh Before Picking a Program?
Six factors deserve a look before you commit to any weight loss provider. Our guide to your first month on weight loss medication explains what to expect once you start:
- Which medications are offered
- Who qualifies medically
- Possible side effects
- How much support the provider gives
- How flexible the plan is
- The total cost of treatment
Side-by-side comparisons such as altRx vs ro, altRx vs TrimRx and embody vs ro make the differences easier to see before you decide.
Which GLP-1 Medications Do Online Programs Prescribe?
Most online weight loss programs prescribe GLP-1 receptor agonists. The common options are listed below, and our explainer on how GLP-1 medications work covers the mechanism in detail:
- Semaglutide
- Tirzepatide
- Liraglutide
Which medication you can get depends on where you live, your medical history and the provider's own policies. Would you rather avoid injections? Read our guide to weight loss pills.
Shop GLP-1 plans by product
Every provider's published plans side by side - cheapest first, with the conditions under each price.
GLP-1 Weight Loss Medications by the Numbers (2026)
Published clinical trial data shows that GLP-1 medications are the most effective prescription weight loss treatments available today. The table sums up the headline results from the major trials.
| Medication | Average Weight Loss | Trial Length | Compounded Price |
|---|
| Semaglutide (Wegovy) | ~15% of body weight | 68 weeks (STEP trials) | From $49/month |
| Tirzepatide (Zepbound) | Up to 20.9% average (22.5% on treatment) | 72 weeks (SURMOUNT trials) | From $89/month |
| Liraglutide (Saxenda) | ~5-8% of body weight | 56 weeks | $1,300+/month (brand only) |
Sources: published results of the STEP (semaglutide), SURMOUNT (tirzepatide) and SCALE (liraglutide) clinical trials. Individual results vary. Compounded prices reflect typical telehealth provider rates as of October 2026.
Tirzepatide vs Semaglutide: How Do They Differ?
Tirzepatide produced greater average weight loss than semaglutide in clinical trials, and the two are the most effective GLP-1 medications for weight loss. Both are weekly injections that work in similar ways, but they differ in trial results, approvals and insurance coverage. Compare tirzepatide providers and semaglutide providers to find the one that suits your goals.
| Factor | Tirzepatide | Semaglutide |
|---|
| Average weight loss in trials | About 15.0%-20.9% average loss at 72 weeks (SURMOUNT) | About 14.9% mean loss at 68 weeks (STEP) |
| FDA approval | FDA-approved for chronic weight management as Zepbound® and for type 2 diabetes as Mounjaro® | FDA-approved for chronic weight management as Wegovy® and for type 2 diabetes as Ozempic® |
| Dosing | Once-weekly injection | Once-weekly injection |
| Best suited to | People aiming for the larger average weight loss seen in clinical trials, when clinically appropriate | People who want an FDA-approved GLP-1 backed by extensive long-term safety and outcomes data |
| Insurance coverage | Not always covered by insurance yet | Varies by insurer; may be listed on more formularies |
Wegovy vs Ozempic: What Is the Difference?
Wegovy and Ozempic contain the same drug, semaglutide; they differ in dose and approved use. Wegovy is made for weight management, while Ozempic was developed for type 2 diabetes and is often prescribed off-label for weight loss. Our Wegovy providers and Ozempic for weight loss guides cover each one in more depth.
| Factor | Wegovy | Ozempic |
|---|
| Average weight loss in trials | About 14.9% mean weight loss at 68 weeks in obesity trials (STEP-1) | 5-10% weight loss seen in type 2 diabetes trials, depending on dose |
| FDA approval | Yes, FDA-approved specifically for weight management | FDA-approved for type 2 diabetes; use for weight loss is off-label |
| Dosing | Once-weekly injection | Once-weekly injection |
| Best suited to | People who want an FDA-approved medication for long-term weight management | People with diabetes who may also benefit from losing weight |
| Insurance coverage | Varies, and coverage for obesity medications is often limited | Coverage may be broader when prescribed for diabetes |
Sources: STEP-1 (semaglutide) and SURMOUNT (tirzepatide) clinical trial data. Zepbound®, Mounjaro®, Wegovy® and Ozempic® are trademarks of their respective manufacturers. Individual results vary, and each of these medications requires a prescription from a licensed clinician.
How Much Does GLP-1 Weight Loss Medication Cost?
Without insurance, brand-name GLP-1 medications cost $900-$1,400 a month at retail. Licensed telehealth providers offer compounded semaglutide and tirzepatide for much less, typically $49-$299 a month with physician consultations, medication and home delivery included. Our GLP-1 cost guide breaks the numbers down.
How Long Does GLP-1 Medication Take to Work?
Most people notice a smaller appetite within the first 1-2 weeks on a GLP-1 medication. Visible weight loss usually starts around weeks 4-8, and clinical trials recorded peak weight loss at 68-72 weeks of treatment. See our semaglutide timeline guide for more detail.
Can You Get GLP-1 Medication Online?
Yes. Licensed telehealth providers can prescribe GLP-1 medications after a fully online medical evaluation, and it typically takes 1-5 days from sign-up to delivery. Every provider featured on Top Weight Loss uses licensed physicians to prescribe and includes ongoing medical oversight. Our guide to getting GLP-1 medication online explains each step.
How Did We Evaluate These Providers?
Each provider's place in the ranking reflects six factors:
- How transparent the pricing is
- Which medications are available
- The level of clinical oversight
- Customer experience
- Plan flexibility
- Overall value
Recommendations are reviewed and updated on an ongoing basis so you can compare weight loss providers with confidence. For more research, browse all of our weight loss guides and articles.