Medvi vs TrimRx vs SHED: Best GLP-1 Program for Support
Last updated: Sep 1, 2026
Reviewed for medical accuracy by Francheska Capistrano, RMT, MPH · Medical Content Reviewer
Clinically checked Checked · Author: Top Weight Loss Research Team · Our review process
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Quick answer
Medvi, TrimRx and SHED all prescribe compounded GLP-1s, but each sells a different kind of support around them, priced from Medvi's current $99 promo up to SHED's $199. Medvi is about care: video visits, a dietician and care coaching, backed by 14,987 Trustpilot reviews. TrimRx is about flexibility: no contract, optional discounts and clinical guidance. SHED is about accountability: formal health coaching plus the market's only guarantee to refund you if you don't lose 5% of your body weight in 120 days.
Prescription weight loss without the hassle
Go to Medvi
Custom-dosed GLP-1 plans with ongoing provider check-ins
Go to TrimRx
20% off your first month of GLP-1 treatment
Go to SHEDHow do Medvi, TrimRx, SHED compare?
Published prices and plan terms for all three providers, row by row, so the real differences are easy to spot.
| Medvi | TrimRx | SHED | |
|---|---|---|---|
| Semaglutide price | $99/mo promo, all-inclusive (reg. $199) | $149/mo at every dose | $199/mo (first month 20% off) |
| Tirzepatide price | $166/mo promo (reg. $299) | $259/mo | $299/mo (first month 20% off) |
| Billing & contract | One all-inclusive monthly price, no surprise charges; HSA/FSA approved | Month-to-month, no contract; discounts on multi-month plans | Billed monthly; HSA/FSA approved |
| Delivery | Free shipping | Free home delivery | Free home delivery |
| Care & support | Video visits plus a free dietician and care coaching | Licensed clinicians guide each dose change | Provider visit and health coaching included |
| Refund or guarantee | - | - | Money back if you don't lose 5% of body weight in 120 days |
| Stands out for | 4.3 Trustpilot rating from 14,987 reviews | Built for flexibility: month-to-month is always an option | The strongest results guarantee on the market |
Which one we recommend
Pick the program that fixes whatever derailed you before. If earlier attempts stalled because you lacked guidance, choose Medvi, whose high-touch care has the review record to back it. If you want premium care without being tied down, choose TrimRx. If you need stakes and structure to stay on track, choose SHED, which pays you back if the program doesn't deliver. At current prices Medvi's $99 promo is also the cheapest of the three, but the style of support, not the price, is the real decision.
Medvi vs TrimRx vs SHED: common questions
Which offers the best support: Medvi, TrimRx or SHED?
Each supports you differently. Medvi includes video visits with providers plus a free dietician and care coaching, and is rated 4.3 across 14,987 Trustpilot reviews. SHED includes formal health coaching backed by a money-back guarantee. TrimRx provides clinical guidance through dose changes within a flexible, no-contract model.
Which of the three has a money-back guarantee?
SHED does: lose 5% of your body weight in 120 days or get your money back, provided you follow the program (terms on its site). Medvi and TrimRx don't advertise a results guarantee.
Are support-focused GLP-1 programs worth paying more for?
The active ingredients match the $49-$99 budget providers, so the extra cost pays for support. If coaching, accountability or a relationship with a provider decides whether you stay on treatment, the higher price can pay off. If you are self-motivated, a budget provider gives you the same medication for less.
References and clinical sources
The medication facts on this page rest on FDA guidance and peer-reviewed clinical trials, while prices and plan terms come from what each provider publishes. Use this page as general information, not medical advice, and speak with a licensed clinician before you start any weight loss treatment.
- 1.Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1 trial) - New England Journal of Medicine, 2021
- 2.Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1 trial) - New England Journal of Medicine, 2022
- 3.FDA Approves New Drug Treatment for Chronic Weight Management (semaglutide / Wegovy) - U.S. Food & Drug Administration, 2021
- 4.FDA Approves New Medication for Chronic Weight Management (tirzepatide / Zepbound) - U.S. Food & Drug Administration, 2023
- 5.FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss - U.S. Food & Drug Administration
- 6.Human Drug Compounding (503A pharmacy standards) - U.S. Food & Drug Administration
- 7.Semaglutide Injection - drug information - MedlinePlus, U.S. National Library of Medicine (NIH)