Medvi vs HealthRx vs DirectMeds: GLP-1 Providers Compared
Last updated: Sep 1, 2026
Reviewed for medical accuracy by Francheska Capistrano, RMT, MPH · Medical Content Reviewer
Clinically checked Checked · Author: Top Weight Loss Research Team · Our review process
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Quick answer
Medvi, HealthRx and DirectMeds each build their GLP-1 program around a different strength. Medvi focuses on people: video visits, a dietician and coaching, with 14,987 Trustpilot reviews averaging 4.3. HealthRx focuses on delivery: $99/month semaglutide on a 12-month prepaid plan ($1,188 at checkout) with overnight cold-chain shipping. DirectMeds focuses on simplicity: one flat $147 price for either medication, as injections or needle-free sublingual drops, with no membership. The table below lines the three up side by side.
Prescription weight loss without the hassle
Go to Medvi
How do Medvi, HealthRx, DirectMeds compare?
Published prices and plan terms for all three providers, row by row, so the real differences are easy to spot.
| Medvi | HealthRx | DirectMeds | |
|---|---|---|---|
| Semaglutide price | $99/mo promo, all-inclusive (reg. $199) | $99/mo, 12-month prepaid ($1,188 due at checkout) | $147/mo at every dose |
| Tirzepatide price | $166/mo promo (reg. $299) | from $179/mo | $147/mo, the same flat rate |
| Billing & contract | One all-inclusive monthly price, no surprise charges; HSA/FSA approved | Prepaid for 12 months; whole year paid at checkout | Monthly with no membership; cancel anytime |
| Delivery | Free shipping | Free overnight cold-chain delivery, lot-tracked | Free, delivered in 1-2 days |
| Care & support | Video visits plus a free dietician and care coaching | Clinician reviews every request; care-team check-ins | Prescribed by a doctor; shots or needle-free drops |
| Refund or guarantee | - | Free assessment, nothing to pay to start | - |
| Stands out for | 4.3 Trustpilot rating from 14,987 reviews | LegitScript certification (cert. 50087439); 503A pharmacies | The only needle-free sublingual drops in our ranking |
Which one we recommend
Choose based on what is most likely to hold you back. If support decides whether you succeed, choose Medvi, which has the strongest review record of the three. If you have already committed to a year and want the best committed price with premium delivery, choose HealthRx. If you want one predictable price that never changes, or you need a needle-free format no one else here offers, choose DirectMeds. All three use licensed clinical review, and none is a legitimacy concern.
Medvi vs HealthRx vs DirectMeds: common questions
Which costs less: Medvi, HealthRx or DirectMeds?
For semaglutide, Medvi and HealthRx both come to $99/month, but Medvi's is a monthly promotional rate (regularly $199) with nothing prepaid, while HealthRx's is a 12-month prepaid plan with $1,188 due at checkout. DirectMeds charges a flat $147/month. For tirzepatide, DirectMeds' flat $147 is cheapest, followed by Medvi at $166 promotional (regularly $299) and HealthRx from $179.
Does Medvi, HealthRx or DirectMeds have a needle-free option?
Only DirectMeds. It offers compounded GLP-1 as sublingual drops taken by mouth as well as weekly injections, both for $147/month. The prescribing doctor decides with you whether drops are a suitable format.
Which of the three ships fastest?
HealthRx is fastest, shipping overnight for free on every plan in temperature-controlled, lot-tracked packaging. DirectMeds ships free in 1-2 days. Medvi includes free shipping on standard timelines.
Compare them in pairs
One-on-one matchups between each pair of these three providers.
References and clinical sources
The medication facts on this page rest on FDA guidance and peer-reviewed clinical trials, while prices and plan terms come from what each provider publishes. Use this page as general information, not medical advice, and speak with a licensed clinician before you start any weight loss treatment.
- 1.Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1 trial) - New England Journal of Medicine, 2021
- 2.Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1 trial) - New England Journal of Medicine, 2022
- 3.FDA Approves New Drug Treatment for Chronic Weight Management (semaglutide / Wegovy) - U.S. Food & Drug Administration, 2021
- 4.FDA Approves New Medication for Chronic Weight Management (tirzepatide / Zepbound) - U.S. Food & Drug Administration, 2023
- 5.FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss - U.S. Food & Drug Administration
- 6.Human Drug Compounding (503A pharmacy standards) - U.S. Food & Drug Administration
- 7.Semaglutide Injection - drug information - MedlinePlus, U.S. National Library of Medicine (NIH)